中文摘要：

翅原基发育分化与昆虫的个体发育紧密联系，对昆虫翅发育的研究有助于阐述昆虫的发育过程。另外，翅的形成是一些农林害虫泛滥的主要原因之一，研究翅发育分化有助于我们从翅发育的角度控制农林害虫。目前，翅发育分化在果蝇Drosophila中研究已较为深入详细。果蝇翅发育分化主要包括4个阶段：翅原基（wingdisc）的确定，前一后（antero—posterior，A—P）和背一腹（dorso-ventral，D—V）组织中心（organizingcenter）的建立，翅区（wingregion）的确定，以及翅区的进一步分化。具有homeobox序列的基因（homeobox基因）如Engrailed（En）、Apterous（却）和Ultrabithorax（Ubx），分泌蛋白如Wnt家族成员Wingless（wg）及TGF—B超家族成员Decapentaplegic（Dpp）和Hedgehog（Hh），以及翅原基特有的核蛋白编码基因Vestigial（增），共同调控了翅原基的正常发育分化。本文综述了果蝇翅原基发育分化的过程及分子机理方面的研究发现，为翅原基的研究提供了参考。

英文摘要：

The development and differentiation of wing disc is closely related with the ontogeny ot insects, and the study on wing disc is helpful to understand the development of insects. Pests with the ability of flight can cause great loss to agriculture and forestry every year, so the study on the development and differentiation of their wing may help to find new targets to control them. The development and differentiation of wing disc in Drosophila was well elucidated. It includes four main processes ： definition of wing disc, establishment of A-P and D-V organizing centers, definition of wing region, and differentiation of wing region. Homeobox genes [ such as engrailed （ En ） , apterous （ Ap ） , and Ultrabithorax （Ubx）], secretory proteins [ such as Wnt family member Wingless （Wg）, and TGF-I3 superfamily members Deeapentaplegic （Dpp） and Hedgehog （Hh） and wing disc specific nuclear protein coding gene Vestigial （Vg） are involved in normal development and differentiation of wing disc. In this article, the research findings on the development and differentiation of Drosophila wing disc and the related molecular mechanisms were reviewed.