中文摘要：

目的：采用细胞划痕实验,研究外源性TGF-β1（transforming growth factor beta）细胞因子对体外分离培养的原代癌相关成纤维细胞（CAFs）迁移特性的影响,探讨TGF-β1细胞因子对CAFs生物学性能的影响。方法：以口腔正常成纤维细胞（NFs）和未经处理的CAFs细胞为对照组,采用细胞划痕实验观察一定浓度的TGF-β1在不同时间作用后对CAFs迁移特性的影响。结果：与NFs组和未处理组CAFs相比,10μg/L的TGF-β1在不同时间点能够明显促进CAFs的迁移。结论：TGF-β1细胞因子能够明显促进CAFs的迁移,对CAFs的生物学性能具有重要影响。

英文摘要：

Objective： To observe the effect of TGF-β1 on the migration of oral carcinoma--associated fibroblasts （CAFs）, and to elucidate the role of TGF-β1 in the cellular characteristics of CAFs. Methods： Untreated CAFs and normal fibroblasts were set as the control group, wound healing assay was used to detect the migration of CAFs after treatment with TGF-β1 for varying periods. Results： Compared with the control groups, 10ng/ml TGF-β1 promoted the migration of CAFs. Conclusion： TGF-β1 can promote the migration of CAFs, and play a key role in CAFs biological characteristics.