中文摘要：

双相情感性精神障碍（BD）是一种严重的精神疾病,具有高患病率、高致残率和高致死率等特点。糖原合成酶激酶-3（GSK-3）是普遍存在于真核细胞内的一种多功能丝氨酸/苏氨酸蛋白激酶,其作用主要包括调节糖原的合成代谢、细胞的分化与增殖以及基因的表达。它参与多条细胞信号传导通路,通过磷酸化调节细胞内许多信号蛋白、结构蛋白和转录因子,进而影响神经元的存活及可塑性。从基因多态性和临床研究发现,GSK-3β可能与BD发生相关。作为GSK-3β抑制剂,锂盐是一种有效的BD治疗药物,以GSK-3β为靶标研发的小分子抑制剂也是BD治疗的热点。综上所述,GSK-3β可能是治疗BD的潜在靶标。

英文摘要：

Bipolar disorder（BD）is a serious mood disorder with high prevalence,morbidity and mortality rates. Glycogen synthase kinase- 3β（GSK- 3β）is a multifunctional serine/threonine protein kinase that is generally located in eukaryotic cells with such functions as the adjustment of the synthesis of glycogen metabolism,cel proliferation and differentiation and gene expression. It is involved in multiple signaling pathways and regulates cell signaling proteins,structural proteins and transcription factors through phosphorylation,affecting the survival of the neurons and plasticity. According to gene polymorphism and clinical studies,GSK-3β may be associated with BD. As a GSK-3β inhibitor,lithium is an effective BD therapeutic drug,and the small molecule inhibitor targeting GSK-3β is also a hotspot of BD treatment. GSK-3β may be a potential target in the treatment of BD.