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中文摘要：
合成了两个钌多吡啶配合物[Ru（bpy）2DMNP]（ClO4）2（Rul）和[Ru（bpy）2BOPIP]（ClO4）2（Ru2），应用元素分析、核磁共振对配合物结构进行了表征，通过电子吸收光谱、荧光光谱、粘度实验以及凝胶电泳技术对配合物与DNA相互作用的性质进行了研究．结果表明，配合物与DNA分子之间以插入模式结合．在紫外光照下，两种配合物均能使质粒pBR322DNA断裂，机理研究表明，其光断裂DNA的活性氧化物种为单线态氧．
英文摘要：
The polypyridyl ruthenium（Ⅱ） complexes of [Ru（bpy）2DMNP]^2＋ and [Ru（bpy）2BOPIP]^2＋ have been synthesized and their structures have been ascertained with elemental analysis and nuclear magnetic resonance spectra. The characteristics of the interaction of the complexes with CT-DNA were examined by Ultra-Vis absorption spectra, fluorescent spectra, viscosity measurements and gel electrophoresis technique. All data indicate that both complexes bind to double-stranded CT-DNA via the intercalative mode and [Ru（bpy）2DMNP]^2＋ binds more avidly to CT-DNA than [Ru（bpy）2BOPIP]^2＋. Noticeably, upon irradiation at 365 nm, the two complexes have been found to efficiently photocleave plasmid DNA, and the active oxygen species for the DNA cleavage in these complexes is singlet molecular oxygen.
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