中文摘要：

目的探讨甲状腺激素T3、T4随季节变化而波动的内在机制。方法选取健康人10名,在设立的8个节气点抽血检测T3、T4的含量;另外,在夏至、冬至日前40d购入大鼠,并根据手术（摘除松果体术）情况分为生理组、假手术组与手术组,饲养到冬至、夏至日,断头取血,检测T3、T4。结果健康志愿者在8个节气点的T3、T4含量存在明显波动,表现为冬春高夏秋低;大鼠在冬夏2个不同节气点的血清T3、T4含量有显著差异,生理组、假手术组和手术组因季节变化而异,即手术与不同节气点之间存在着交互作用。结论甲状腺激素在健康人群中存在着冬夏季节变化,动物实验证明,其冬高夏低的变化规律与松果腺的高位调节机制密切相关。

英文摘要：

Objective To investigate the internal mechanism of fluctuation of T 3 and T4 under the influences of seasonal variations.Methods Ten healthy volunteers were selected and the content of T3 and T4 in the blood samples collected from them were detected at 8 assigned solar terms.Meanwhile,rats were bought 40 days before the Summer Solstice and Winter Solstice,and then they were divided into the physiology group,sham-operation group and operation group according to their operation status.The rats were feed until to the day of the Summer Solstice and Winter Solstice and killed for detecting the content of T3 and T4.Results The content of T3 and T4 had significant variations in the healthy volunteers at the 8 solar terms showing higher in winter and spring,and lower in summer and autumn.The content of T 3 and T4 was significantly different between two solar terms of winter and summer in rats.There was the interactions between operations and solar terms.Conclusion The thyroid hormones have changes in winter and summer in healthy people.The animal experiment has proved that the change laws of thyroid hormones,showing higher in winter and lower in summer,are correlated closely to the up-regulation mechanism of pineal gland.