由一个一个壶的 3,5-dicyano-1,2-dihydropyrid-2-ones 的简单、干净的合成 malononitrile,芳香的醛和 2-cyanoacetamide 或 2-cyanothioacetamide 的三部件的反应在微波照耀下面作为一个底与钾碳酸盐在一个水的答案被完成了没有阶段转移试剂。这个协议有短反应时间(58 min ) 和方便病情的检查的优点。
A simple and clean synthesis of 3,5-dicyano-1,2-dihydropyrid-2-ones by a one-pot three-component reaction of malononitrile, aromatic aldehydes and 2-cyanoacetamide or 2-cyanothioacetamide has been achieved in an aqueous solution with potassium carbonate as a base under microwave irradiation without a phase transfer reagent. This protocol has the advantages of short reaction time (5-8 min) and convenient work-up.