发展了手性路易斯碱催化的2-位无取代基的二芳基甲酮亚胺的不对称氢化硅烷化反应,在20 mol%的最优催化剂催化下,以良好的收率(最高达97%)和中等到良好的对映选择性(最高达89%)获得了一系列手性二芳基甲胺类化合物,并通过单晶X射线衍射的方法确定了其中一个反应产物的绝对构型.
Lewis base catalyzed enantioselective hydrosilylation of non-ortho-substituted N-aryl diaryl ketimines was realized. In the presence of 20 mol% of the optimal catalyst, the reactions provided a series of (diarylmethyl)amines with high yields (up to 97%) in moderate to good enantioselectivities (up to 89% ee). The absolute configuration of one product was determined by X-ray crystallographic analysis.