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Uniform design ray in the assessment of combined toxicities of multi-component mixtures
  • 期刊名称:Science Bulletion
  • 时间:2015.12.19
  • 页码:2111-2117
  • 分类:TQ018[化学工程] O212.6[理学—概率论与数理统计;理学—数学]
  • 作者机构:[1]Key Laboratory of Yangtze River Water Environment, Ministryof Education, College of Environmental Science andEngineering, Tongji University, Shanghai 200092, China, [2]College-of Environment and Energy Engineering, Anhui JianzhuUniversity, Hefei 230601, China
  • 相关基金:supported by the National Natural Science Foundation of China(21177097;21207002);Specialized Research Fund for the Doctoral Program of Higher Education(20120072110052)
  • 相关项目:部分PPCP污染物及其混合物对水生生物时间毒性与作用机制研究
中文摘要:

多部件混合(看) 是与各种各样的混合比率包含很多混合光线的一个复杂化学系统,并且每条光线与不同集中层次包括许多混合物。在联合毒性地里,当前,看上的研究在混合物上集中的几乎所有由相等效果的集中比率(EECR ) 设计了过程。然而,因为 EECR 混合物在多重部件形成的集中空间位于一条混合光线, EECR 混合物不能代表整个混合系统。在我们看来,象一致设计(UD ) 那样的某最佳的试验性的设计应该被用来有效地从 MCM 系统选择许多代表性的混合光线,而不是单个 EECR 光线。与改正比率光线设计集成 UD 想法的一致设计光线(UD 光线) 能系统地并且包括地在 MCM 系统测量联合毒性变化。这评论介绍操作方法,一致桌子的构造和相应可用的桌子,和容易帮助读者的 UD 光线的申请的一些盒子在他们的看毒性评价使用 UD 光线。

英文摘要:

Multi-component mixture (MCM) is a com- plicated chemical system that contains a great deal of mixture rays with various mixture ratios, and each ray includes many mixtures with different concentration levels. Currently, in combined toxicity field, almost all studies on MCM focus on the mixtures designed by the equivalent- effect concentration ratio (EECR) procedure. However, the EECR mixtures cannot represent the whole mixture system because the EECR mixtures are located on one mixture ray in concentration space formed by multiple components. In our view, some optimal experimental design such as the uniform design (UD) should be used to effectively select many representative mixture rays from the MCM system, instead of single EECR ray. The uniform design ray (UD- ray) integrating UD idea with fixed-ratio ray design can systematically and comprehensively measure the combined toxicity changes in the MCM system. This review intro- duces the operation method, construction of uniform table and corresponding usable table, and some cases of application of the UD-ray to help readers easily use UD-ray in their MCM toxicity assessment.

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