目的通过电针刺激胃缺血再灌注大鼠足三里穴,观察电针对缺血再灌注状态下胃血流和功能的影响。方法采用胃缺血再灌注组(对照组)与电针刺激病理模型组,使用激光多普勒血流仪和多导生理记录仪观察记录电针足三里穴时缺血再灌注状态下胃血流和胃电快波。结果在阻断血流过程中电针组血流量的减少小于对照组,25min时与对照组比较差异有统计学意义(P〈0.05);松解过程中电针组血流量的增加大于对照组;电针组胃电幅度在缺血状态下与再灌注状态比较显著升高(P〈0.05);对照组胃电快波频率在阻断血流状态下比正常状态有显著性差异(P〈0.05),电针组胃电快波频率在松解状态与正常状态相比差异有统计学意义(P〈0.05)。结论电针刺激足三里穴在胃缺血再灌注过程中对血流的变化是在不同状态下均是增加血流量的作用;对胃电运动的影响在机体不同状态下、胃当时的机能状态等都具有相关性,总体上对胃电活动是抑制的作用。
Objective To investigate the effect of electroacupuncture on gastric blood flow and function during ischemia and reperfusion by its stimulation of point Zusanli(ST36)in gastric ischemia-reperfusion rats.Methods A gastric ischemia-reperfusion group(control)and an electroacupuncture model group were established.When electroacupuncture was performed at point Zusanli, gastric blood flow and electrogastrographic fast waves under gastric ischemia and reperfusion were examined using a laser Doppler hemodromograph and a multichannel physiological recording system.During the interruption of blood flow,its volume decreased less in the electroacupuncture group than in the control group,and there was a statistically significant difference at 25 min(P0.05). During the restoration of blood flow,its volume increased more in the electroacupuncture group than in the control group.In the electroacupuncture group,the electrogastrographic wave amplitude was significantly higher under ischemia than under reperfusion (P0.05).In the control group,there was a statistically significant difference in the electrogastrographic fast wave frequency between under the interruption of blood flow and under the normal condition(P0.05).In the electroacupuncture group,there was a statistically significant difference in the electrogastrographic fast wave frequency between under the restoration of blood flow and under the normal condition(P0.05).Conclusion Electroacupuncture stimulation of point Zusanli has an effect of increasing blood flow volume under different conditions of blood flow during gastric ischemia and reperfusion.Its effect on the gastric electrical activity correlates with the concomitant gastric function in different body conditions.Overall,it has an inhibitory effect on the gastric electrical activity.