中文摘要：

目的：探讨 MR 弥散张量成像和灌注成像在大鼠 C6脑胶质瘤模型诊断中的意义。方法：构建大鼠 C6脑胶质瘤模型，选择肿瘤最大层面分别获取 Ktrans、Kep、Ve、MD 和 FA 图。结果：Ktrans、Kep、Ve、MD 和 FA 值在肿瘤区域、坏死区域和正常脑组织均存在统计学差异（P〈0.001）。 Ktrans 值与 Kep 值呈高度正相关（肿瘤区域：0.932，P〈0.001；坏死区域：0.921，P〈0.001；正常组织：0.071，P ＝0.676）；扣除 Ktrans值的影响，Kep 值和 Ve 值呈负相关（肿瘤区域：-0.602，P〈0.001；坏死区域：-0.617，P〈0.001；正常组织：0.084，P＝0.626）；扣除 Kep 值的影响，Ktrans 值和 Ve 值呈正相关（肿瘤区域：0.406，P ＝0.014；坏死区域：0.582，P〈0.001；正常组织：0.275，P＝0.105）。 FA 值和 MD 值呈现负相关（肿瘤区域：-0.898，P〈0.001；坏死区域：-0.782，P〈0.001；正常组织：-0.478，P＝0.003）。结论：MR 弥散张量成像和灌注成像有助于胶质瘤模型中肿瘤区域、坏死区域和正常脑组织的鉴别。

英文摘要：

Objective：To assess the diagnosis with DTI and PWI in the model of rat C6 gliomas.Method：Maps of Ktrans、Kep、Ve、MD and FA from the maximum slice of tumor were obtained with the model of rat C6 gliomas.Result： Values of Ktrans, Kep, Ve, MD and FA were statistically different among regions of tumor、necrosis and normal tissue （P〈0.001）.There were high correlation between Ktrans and Kep （tumor：0.932,P〈0. 001; necrosis：0.921,P〈0.001;normal tissue：0.071,P = 0.676）.Removing the effect of Ktrans,Kep and Ve were negatively correlated （tumor：- 0.602,P〈 0.001; necrosis：- 0.617,P〈 0.001; normal tissue：0.084,P =0. 626）.Removing the effect of Kep,Ktrans and Ve were positively correlated （tumor：0.406,P= 0.014; necrosis：0.582,P〈0.001; normal tissue：0.275,P = 0.105）.FA and MD were negatively correlated（tumor：-0.898,P〈0. 001; necrosis：-0.782,P〈 0.001; normal tissue：- 0.478,P = 0.003）. Conclusion：DTI and PWI would be hopeful for the diagnosis of the regions of gliomas,necrosis and normal tissue.