中文摘要：

目的 探讨宁夏地区非综合征型唇腭裂（NSCL/P）发病相关环境因素。方法 采用病例对照研究方法纳入NSCL/P患者453例,正常新生儿452例。对研究对象进行问卷调查,利用SPSS 16.0统计软件对数据进行卡方检验和Logistic回归分析。结果 NSCL/P患病类型构成比为唇裂︰唇裂合并腭裂︰腭裂=1︰2.02︰1.51。Logistic回归分析显示妊娠期发生异常、妊娠期感染、流产史、孕前孕中服用药物、饮茶、吸烟、饮酒、居住地附近工厂为危险因素（P〈0.05）。单胎、早孕反应、食用豆制品食物、水果为保护因素（P〈0.05）。结论 加强母亲孕期饮食均衡,避免感染、流产、服用药物以及不良生活习惯对降低NSCL/P的发生具有重要意义。

英文摘要：

Objective To investigate the association between non-syndromic cleft lip with or without cleft palate （NSCL/ P） and environmental factors in Ningxia population. Methods This case-control study involved 453 NSCL/P patients and 452 normal newborns from Ningxia. A questionnaire focusing on various factors, including family history, pregnancy reaction, drug use during pregnancy, and infections, was used and responses were analyzed through Chi-square test and Logistic regres- sion analysis with SPSS 16.0. Results The constituent ratio of different types of NSCL/P was cleft lip ： cleft lip and palate ： cleft palate equal to 1 ： 2.02 ： 1.51. Logistic regression analysis revealed that abnormal pregnancy, infection, abortion, drugs, drinking, smoking, and living near factories likely increased the risk of NSCL/P （P〈0.05）. Single fetus, pregnancy-related nausea, vomiting, parents＇ moderate tastes, and eating soy foods and fruits decreased the risk ofNSCL/P （P〈0.05）. Conclusion The incidence of NSCL/P should be reduced to enhance the conditions of women during pregnancy by maintaining a balanced diet and avoiding infections, abortion, drugs, and negative habits.