中文摘要：

Apolipoprotein A-I (apoA -- 我) 是高密度的脂蛋白的主要功能的蛋白质部分。人的 apoA 的预防效果和机制 -- 我在动脉粥样硬化上(作为) 被调查在一高脂肪象兔子模型导致食谱。兔子与 apoA 被注射 -- 我每周一次当喂时为 20 个星期的高脂肪的饮食。我们的结果显示出那 apoA -- 我能提起高密度的脂蛋白胆固醇的浆液水平并且类脂化合物总数胆固醇， triglyceride，和低密度的脂蛋白胆固醇减少那些在作为兔子。减少的大动脉的匾区域和大动脉的损害度被染色的油红 O 也观察并且他在 apoA-I-treated 染色高脂肪象兔子导致食谱。进一步的学习阐明了那 apoA -- 我能包括细胞间的粘附分子的一些煽动性的调停人的表示打的下面调整 1，脉管的粘附 molecule-1 (VCAM-1 ) ，单核白血球 chemoattractant protein-1，肿瘤坏死因素 -- ， interleukin-6 (IL-6 ) ，和在浆液和主动脉的 C 反应的蛋白质作为兔子。另外，即时量的 RT-PCR 分析证明 apoA --我注入减少了二个 支持inflammatory 分子的 mRNA 层次，即原子因素 kappa B ( NF-B )和 cyclooxygenase-2 ( COX-2 )，在主动脉作为兔子，它在 endothelial VCAM-1 和 IL-6 mRNA 抄写与伴随物减小被联系。一起，我们的结果支持 atheroprotective 和 apoA 的预防角色 -- 我可以与它的反煽动性的效果在 vivo，和这项活动被相关。

英文摘要：

Apolipoprotein A-I （apoA-I） is the major functional protein fraction of high-density lipoprotein. The prophylactic effect and mechanism of human apoA-I on atherosclerosis （AS） were investigated in a high-fat diet-induced AS rabbit model. The rabbits were injected with apoA-I once a week while fed high-fat diet for 20 weeks. Our results showed that apoA-I could raise the serum level of high- density lipoprotein-cholesterol and reduce those of lipid total cholesterol, triglyceride, and low- density lipoprotein-cholesterol in AS rabbits. Decreased aortic plaque area and aortic injury degree were also observed by Oil Red 0 staining and HE staining in apoA-I-treated high-fat diet- induced AS rabbits. Further study elucidated that apoA-I could down-regulate the expression of some inflammatory mediators including intercellular adhesion molecule type 1, vascular adhesion molecule-1 （VCAM-1）, monocyte chemoattractant protein-I, tumor necrosis factor-s, interleukin-6 （IL-6）, and C-reactive protein in serum and aorta of AS rabbits. In addition, real-time quantitative RT-PCR analyses showed that the apoA-I infusions decreased the mRNA levels of two pro- inflammatory molecules, i.e. nuclear factor kappa B （NF-~B） and cyclooxygenase-2 （COX-2）, in aorta of AS rabbits, which was associated with a concomitant reduction in endothelial VCAM-1 and IL-6 mRNA transcription. Together, our results support the atheroprotective and prophylactic role of apoA-I in vivo, and this activity may be correlated with its anti-inflammatory effect.