中文摘要：

氟中毒是一种氟过度蓄积的地方病,常常造成严重的氟斑牙和氟骨症,近年来,随着表观遗传学的发展,大量研究从表观遗传对氟中毒发病机制进行探索,研究发现SIRT1对氟中毒的发生发展有重要作用,氟暴露可导致卵巢和子宫结构损伤而降低雌鼠的生育能力。SIRT1可通过p53调控生殖激素的分泌,SIRT1升高的保护作用可能与其对甲基化的调控有关。本文将对SIRT1与氟中毒生殖功能损伤的关系进行综述,为进一步探索氟中毒的发病机制提供科学依据。

英文摘要：

Fluorosis is an endemic disease caused by excessive accumulation of fluoride, which often results in severe dental fluorosis and skeletal fluorosis. In recent years, the epigenetic pathogenesis of fluorosis has been explored by many researchers and it was found that SIRT1 plays an important role in the pathogenesis of fluorosis Fluoride exposure can cause structural damage to the ovary and uterus in fluorosis rats and thus reduce the fertility of female rats. SIRT1 can regulate the secretion of reproductive hormones through p53, and the protective effect of SIRT1 may be related to the regulation of methylation by SIRT1. This article summarized the present studies and prospects of the relationship between SIRT1 and fluorosis, hoping to provide scientific basis for further exploration of the pathogenesis of fluorosis