从中药提取物、单味中药、中药复方制剂三个方面,综述了中药对神经胶质细胞活性的影响。中药调节神经胶质细胞活性的机制可能包括:(1)抑制iNOS表达,从而抑制NO及其产生的氧自由基的毒性;(2)抑制脑缺血和脑出血急性期星形胶质细胞的过度活化和GFAP的过度表达;(3)上调缺血损伤导致的神经胶质细胞分泌NGF;(4)抑制神经系统的免疫炎症反应等各种途径。
This article reviews the effects of traditional Chinese medicine(TCM) on glial cells, including 7 extractives, 1 component, and 7 compounds. TCM may modulate the glial ceils through the following mechanisms : inhibiting expression of iNOS, thereby minishing the toxicity of NO and its oxygen free radicals; inhibiting overactivation of astrocytes and overexpression of GFAP in acute cerebral ischemia and cerebra/hemorrhage; promoting glial ceils' secretion of NGF which can be caused by ischemic injury; inhibiting the nervous system's immune inflammatory response; and so on.