欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
中文摘要：
Notch信号通路在细胞决定、发育、分化、增殖、凋亡、粘附及上皮一间质细胞转化过程中发挥重要作用，并参与了心脏发育的关键过程，也与心肌再生修复密切相关，Notch位点突变可引起一系列心脏畸形。本综述将集中讨论Notch信号通路及其在心脏发育、先天性心脏病和心肌再生中的作用。
英文摘要：
Notch signaling is essential for cell fate decisions, cellular development, differentiation, prolifera- tion, apoptosis, adhesion and epithelial-to-mesenchymal transition. Notch signaling plays a critical role during mammalian cardiogenesis, and is closely related to myocardial regeneration and repair. The mutations in the Notch signaling has been associated with human congenital heart diseases. Therefore, this review focuses on the progress of Notch signaling and its role in cardiac development, congenital heart disease and myocardial regeneration.
同期刊论文项目
同项目期刊论文
期刊信息
位置：