中文摘要：

目的 评价热毒宁注射液（金银花、栀子及青蒿）及其降解产物的过敏性和溶血反应.方法 选用豚鼠、大鼠和新西兰兔静脉注射热毒宁注射液及其降解产物后观察豚鼠主动全身过敏反应、大鼠被动皮肤过敏反应和新西兰兔溶血反应的影响.结果 在实验剂量下,热毒宁注射液及其降解产物对豚鼠的主动全身过敏反应、大鼠的皮肤过敏反应及溶血试验均为阴性.结论 热毒宁注射液及其降解产物的动物实验表明临床用药安全.

英文摘要：

AIM To evaluate the possible allergic reaction and hemolyzation in Reduning Injection （Lonicerae japonicae Flos, Gardeniae Fructus and Artemisiae annuae Herba ） and their degradation products. METHODS Active systemic anaphylaxis （ASA） in guinea pigs and passive cutaneous anaphylaxis （PCA） in rats and rabbits inhemolytic test were performed respectively. RESULTS The results of animal experiments showed that the data on Reduning Injection and their degradation products were all negative as compared with those on the control group. No allergic reaction on passive cutaneous anaphylaxis in guinea pigs and active systemic anaphylaxis in rats, and no evidences of hemolyzation and aggregation on rabbit erythrocytein in vitro were observed. CONCLUSIONS Re- duning Injection and their degradation products are safe at the animal level.