中文摘要：

制备了新的Aβ斑块显像剂^99Tc^m-酰胺基氨基二硫醇（MAMA）-4-氨基-4’-二甲氨基联苯（DMABP），并研究了其在正常小鼠体内的生物分布。实验结果表明,^99Tc^m-MAMA—DMABP具有较高的初始脑摄取，较快的正常脑组织清除，尾静脉注射后2min的脑摄取达0．88％／g，2min与60min的脑摄取率比值为2．8。

英文摘要：

Alzheimer＇s disease （AD） is a neurodegenerative disease of the brain. Radioactive imaging agents for β-amyloid plaques in the brain will be useful in early noninvasive diagnosis and monitoring the progression of the disease. A new imaging agent for β-amyloid plaques, ^99Tcm-MAMA-DMABP was prepared, and its biodistribution in normal mice was studied. The results indicate that ^99Tcm-MAMA-DMABP has fairly high initial brain uptake and fast brain clearance in normal mice. Brain uptake is 0. 88%/g at 2 min post i.v. injection. Brain uptake ratio （2 min/60 min） is 2.8.