中文摘要：

目的研究透骨消痛胶囊治疗骨性关节炎的药理学机制。方法利用生物网络的度分布、路中心、最近距离中心、特征路径长度、异质性等网络特征参数，对透骨消痛胶囊中分子配体-靶作用网络和药物库中药物分子配体-靶作用网络对照研究透骨消痛胶囊的药理学机制。结果2个网络都属于无标度网络，存在一些“关键节点”，2个网络的异质性和特征路径长度值接近。结论透骨消痛胶囊和药物分子配体-靶作用网络中存在“一对多、多对一”复杂的非线性调控模式，揭示了透骨消痛胶囊的多向药理学行为。

英文摘要：

Objective To study the pharmacological mechanism of Tougu Xiaotong capsule （TGXTC）. Methods The parameters of network features, including degree distribution, betweenness centrality, closeness centrality, characteristic path length and network heterogeneity were used in the experiment, and TGXTC ligand-target interaction network and drug ligand-target interaction network were compared. Results Network features showed that both networks belong to scale-free networks and have some key points. The values of heterogeneity and characteristic path length in both networks were close. Conclusion The nonlinear regulation pattern of ＂one to many, many to one＂ exists in TGXTC ligand-target interaction network and drug ligand-target interaction network, which reveal the pharmacological behavior of TGXTC.