中文摘要：

目的：探讨首发青少年抑郁症患者大脑结构异常脑区的形态学改变。方法收集青少年首发抑郁症患者16例及健康志愿者16例,行 MRI形态学检查。随后对数据利用基于优化的体素的形态学分析方法观察青少年抑郁症患者大脑受损脑区的变化。结果与正常健康对照组相比,青少年首发抑郁症患者左侧背外侧前额叶皮层（DLPFC）,右侧梭状回（fusiform）灰质体积减小。左侧DLPFC的灰质密度与抑郁症的汉密尔顿抑郁量表（hamilton depression scale,HAMD）评分呈负相关。结论青少年首发抑郁症患者存在左侧DLPFC和右侧 Fusiform灰质异常,并且左侧DLPFC的灰质密度与 HAMD评分呈负相关。

英文摘要：

Objective To explore the morphological changes of the brain structure in youngsters first-episode depression.Methods Collecting 1 6 youngsters patients with first-episode depression and 1 6 healthy volunteers,separately examining morphological changes in their brain regions by MRI,and then analyzing data by Voxel-Based Morphometry in order to observe the damaged brain areas in depression patients.Results Comparing with control group,gray mater volume of the left dorsolateral prefrontal cortex and right fusiform gyrus decreased in depression patients.The gray matter density of left dorsolateral prefrontal cortex showed negative correlation with HAMD scores.Conclusion The gray matter decreased in left dorsolateral prefrontal cortex and right fusiform gyrus in youngsters first-episode depression patients.In addition,the gray matter density of left dorsolateral prefrontal cortex had negative correlation with HAMD scores.