中文摘要：

血脂异常与动脉粥样硬化密切相关，是心血管疾病尤其是冠状动脉粥样硬化性心脏病发生和发展的重要危险因素。致动脉粥样硬化最强的低密度脂蛋白胆固醇主要通过特异识别与结合低密度脂蛋白受体后被内吞入细胞转变为胆汁酸，类固醇，维生素D3（VD3）等，即低密度脂蛋白受体途径降解。本文阐述了低密度脂蛋白受体基因结构。突变位点．多态性及血脂代谢关系的研究进展。

英文摘要：

Dyslipidemia is strongly correlated with atherosclerosis as dyshpidemla is a major risk factor for cardiovascular disease,especially atherosclemtic coronary artery disease. Low density hpoprotein is the worst hpid that leads to atherolosis. Low density lipoproteins is rich in cholesterol. Through apohpoprotein E and apolipoprotcin BI00 binding to their specific receptors on the cell membrane and acting on themselves, low density lipoproteins pass across the cell membrane and then decompose to bile acid, steroid and vit D3, etc,inside the cell. This article concerned with the recent advancement studying of genetic structure of low density lip- oprotein receptors genes that code for apo E and apoB100,genetic mutations and genetic polymorphism,blcod lipid metabolism as well.