中文摘要：

胰岛素（insulin）/胰岛素样生长因子1（insulin-like growth factor 1,IGF-1）信号通路在细胞的分化、生长、生存及代谢起非常重要作用。胰岛素信号传递首先需要胰岛素/IGF-1与胰岛素受体（insulin receptor,IR）结合,磷酸化胰岛素受体底物（insulin receptor substrates,IR Ss）后形成一个紧密连接的三聚物。磷酸化的IRSs作为停靠蛋白（docking protein）再激活一系列包含Src同源结构域2（SH2）的蛋白,引起相应的生物学效应。目前发现IRSs从IRS-1到IRS-6共6种,它们的分布存在明显的组织特异性,IRS-1、2在人体多种组织中分布广泛;IRS-3则在脂肪组织中居多;而IRS-4、5、6在人体组织表达相对较低。本文拟对IRSs在组织中分布特异性与功能作一综述。

英文摘要：

Insulin/Insulin-like growth factor 1（IGF-1） signaling pathway plays important roles in cell differentiation,growth,survival and metabolism.Firstly,insulin/IGF-1 binds with insulin receptor to phosphorylate insulin receptor substrates（IRSs）,which forms a tightly coupled trimer and then the phosphorylated IRSs activate a series of downstream Src homology 2（SH2） containing proteins such as docking proteins,and then initiated a series of corresponding biological effects on target cells.there are 6 members in IRSs family from IRS-1 to IRS-6 among which the distribution is distinct from each other in various tissues.IRS-1 and IRS-2 distribute widely in different tissues and IRS-3 expresses more in adipose tissue while IRS-4,IRS-5 and IRS-6 distribute very few in human tissues.Here we summarized the tissue specii c functions of insulin receptor substrate family members based on their molecular structures.