中文摘要：

目的观察表皮生长因子受体（epidermal growth factor receptor,EGFR）和转化生长因子β1（transforming growth factor-β1,TGF-β1）在慢性鼻窦炎患者鼻窦黏膜上皮的表达及分布,探讨EGFR和TGF-β1在慢性鼻窦炎发生发展中的作用。方法选取鼻内镜手术患者30例,实验组慢性鼻窦炎伴/不伴鼻息肉组各10例,对照组为10例无鼻窦炎症接受经鼻手术患者。所有患者均于术中取钩突黏膜置于10%福尔马林中固定,应用HE染色方法和免疫组织化学方法,分别观察EGFR和TGF-β1在两组鼻窦黏膜上皮的表达情况。结果对照组和实验组鼻窦黏膜上皮内EGFR和TGF-β1均有表达,EGFR在实验组两组鼻窦黏膜上皮内的表达均显著高于对照组（P〈0.05）,EGFR在实验组两组鼻窦黏膜上皮内的表达无显著性差异（P〉0.05）;TGF-β1在实验组两组鼻窦黏膜上皮内的表达显著高于对照组（P〈0.05）,TGF-β1在实验组鼻窦炎不伴鼻息肉组鼻窦黏膜上皮内的表达显著高于鼻窦炎伴鼻息肉组（P〈0.05）。结论 EGFR和TGF-β1在鼻窦炎伴/不伴鼻息肉患者鼻窦黏膜中的异常表达可能与慢性鼻窦炎的发生、发展有关。

英文摘要：

Objective To analyze the localization and expression of epidermal growth factor receptor（ EGFR） and transforming growth factor-β1（ TGF-β1） in sinus mucosal epithelium of patients with chronic rhinosinusitis（ CRS） and explore the role of EGFR and TGF-β1 in the development of CRS. Methods Thirty patients undergoing endoscopic sinus surgery were recruited. Ten CRS patients with nasal polyps（ NP） and ten CRS patients without NP were included as two experimental groups respectively. The control group comprised ten non-CRS patients undergoing endoscopic sinus surgery. All ethmoidal mucosal specimens were collected at surgery and fixed with 10% formalin. HE staining and immunohistochemical staining were used to examine the localization and expression of EGFR and TGF-β1. Results GFR and TGF-β1were expressed in the sinus mucosal epithelial cells both in experimental groups and control group. The expression of EGFR and TGF-β1 in experimental groups was significantly higher than that in control group（ P〈0. 05）. There was no significant difference in EGFR expression between the CRS with NP group and CRS without NP group（ P〉0. 05）,while the expression of TGF-β1 in the CRS without NP group was higher than that in CRS with NP group（ P〈0. 05）. Conclusion The abnormal expression of EGFR and TGF-β1 in the sinus mucosal epithelium in CRS may be related with the development of CRS.