中文摘要：

以二氧化硅（SiO2）为模板,N-异丙基丙烯酰胺（NIPAm）为壁材,制备温敏性纳米囊。采用透视电镜（TEM）、红外（FT-IR）、热重（TGR）和紫外（UV）等技术对纳米囊的理化性质进行测定。以孔雀石绿为模型分子,考察纳米囊对孔雀石绿的装载效果。结果表明：温敏性聚合物NIPAm成功包覆于SiO2表面,氢氟酸（HF）能够较好去除SiO2,形成具有可逆响应温敏性纳米囊;温敏性纳米囊在室温下对孔雀石绿具有较好的装载效果。因此,本实验为开发新型的温敏性给药系统提供了一定参考。

英文摘要：

Temperature-sensitive nanocapsules were prepared using SiO2 as template and N-isopropylacrylamide（NIPAm） as temperature-sensitive polymer,respectively.And the characterizations were investigated by TEM,FT-IR,TGR and UV techniques.Nanocapsules were applied to load of malachite green.The results indicated that NIPAm was grafted successfully onto the surface of SiO2.The nanocapsules were formed after removal of SiO2 by HF solutions.The nanocapsules have the ability of reversible temperature-sensitive with higher loading capability.Thus,the application of such temperature-sensitive nanocapsules might offer a potential technology for drug delivery.