中文摘要：

目的：研究尼膜同对大鼠脑出血后核转录因子．KB（NF-κB）表达的影响。方法：将SD大鼠随机分成正常组、假手术组、脑出血模型组、尼膜同治疗组。采用Ⅶ型胶原酶注入到大鼠右侧苍白球制备脑出血模型，每组分别在术后6、24、48、96h4个时间点收取脑组织标本．免疫组化检测NF-κBP65蛋白表达，同时测量脑组织含水量。结果：与正常组和假手术组比较，大鼠脑出血后脑组织NF-κB P65表达以及脑组织含水量显著增高（P〈0．01）；与脑出血模型组比较，尼膜同治疗组NF-κB P65水平及脑组织含水量均显著降低（6h，P〈0．05；24、48、96h，P〈0．01）。结论：屉莫通可以抑制脑出血后NF-κB表达，这可能是尼膜同减轻脑出血后脑水肿的机制之一。

英文摘要：

Objective： To study the influence of nimotop on the expression of NF-κB in perihematomal brain regions of rats. Methods： Male Sprague -Dawley rats were randomly divided into normal group （group A） , pseudo-operation group （group B）, model group （group C） and nimotop treatment group （group D）.ICH models were induced in rats by injecting Ⅶ type collagenase into the fight globas pallidus. The brain tissue specimens in every group were respectively gathered at the time of 6 h,24 h ,48 h and 96 h after operation. The expression of NF-KB in rat brain after ICH was detected with immunohistochemistry method, at the same time the moisture in brain tissue was measured. Results： Compared with group A and group B , the expression of NF-κB and moisture in brain tissue in group C were obviously increased （P 〈 0. 01） . Compared with group C , the expression of NF-κB and moisture in brain tissue in group D were obviously decreased （P 〈 0.05 ,or P 〈 0.01 ）. Conclusion： Nimotop can reduce the expression of NF - κB in rat after ICH, which may be related with the anti-edema effect following ICH.