中文摘要：

为了改善泊洛沙姆温敏水凝胶的性能,用5种不同化学结构的多糖及多糖衍生物与泊洛沙姆制备温敏水凝胶,研究这些多糖的化学结构对水凝胶性能的影响。结果表明多糖及多糖衍生物与泊洛沙姆在接近体温（34-37℃）时形成水凝胶,有利于实现可注射使用的目的。两亲性多糖衍生物/泊洛沙姆温敏水凝胶的稳定性更高,体现出更强的剪切变稀性质,缓释疏水性药物—强的松的时间更长,这些性质可能与两亲性海藻酸钠衍生物和两亲性壳聚糖衍生物与泊洛沙姆之间存在疏水相互作用力有关。5种温敏水凝胶体均表现出促进成骨细胞增殖生长的性能,在骨关节组织具有一定的应用前景。

英文摘要：

To improve the property of poloxamer hydrogels,temperature sensitive hydrogels were prepared from poloxamer and five kinds of polysaccharides as well as their derivatives with different chemical structures in this work. The effect of the chemical structures of polysaccharides and their derivatives on the hydrogel properties was investigated. The result indicated that the polysaccharides and their derivatives could form the hydrogels with poloxamer at the temperature（ 34 - 37 ℃） near human beings＇ temperature,which is advantageous for the injection application. The amphiphilic polysaccharide derivative /poloxamer hydrogels exhibited higher stabilities,stronger shear thinning behaviours,longer time for releasing hydrophobic drug of prednisone. These properties are probably related to the hydrophobic interactions between the amphiphilic polysaccharide derivatives and poloxamer. Five kinds of temperature sensitive hydrogels all exhibited the property for promoting the growth of osteoplasts,showing the potential application in the osseous junction＇s tissues.