中文摘要：

瞄准：为了在严重尖锐胰腺炎(树液) 的死亡的减小调查预防抗菌素的角色，病人，它是高度由越来越使随机化的控制试用(RCT ) 和元分析询问了。方法：更新的元分析被执行。为树液把预防抗菌素与控制或安慰剂作比较的 RCT 为元分析被包括。死亡结果被分享因为评价，和重新分享的评价被理想的大规模 RCT 的敏感分析执行。结果：当前可得到 11 RCT 被包括。，亚群分析证明有在在 2000 前的时期的死亡率的重要减小在从 2000 的时期的没有重要减小[风险比率，(RR )= 1.01， P = 0.98 ] 。漏斗阴谋显示可能在在 2000 前的时期有明显的出版偏爱。敏感分析证明死亡率的 RR 与相对狭窄的信心间隔从 0.77 ～ 1.00 (P < 0.05 ) 。然而，数字需要对待有暗示的范围(7-5096 病人) 的次要的更低的限制某些树液病人能仍然潜在地由抗菌素预防阻止死亡。结论：当前的证据不为树液作为平淡的治疗支持预防抗菌素，但是潜在地有益于的亚人口要求进一步的调查。

英文摘要：

AIM： To investigate the role of prophylactic antibiotics in the reduction of mortality of severe acute pancreatitis （SAP） patients, which is highly questioned by more and more randomized controlled trials （RCTs） and metaanalyses. METHODS： An updated meta-analysis was performed. RCTs comparing prophylactic antibiotics for SAP with control or placebo were included for meta-analysis. The mortality outcomes were pooled for estimation, and re-pooled estimation was performed by the sensitivity analysis of an ideal large-scale RCT. RESULTS： Currently available 11 RCTs were included. Subgroup analysis showed that there was significant reduction of mortality rate in the period before 2000, while no significant reduction in the period from 2000 [Risk Ratio, （RR ） = 1.01, P = 0.98]. Funnel plot indi-cated that there might be apparent publication bias in the period before 2000. Sensitivity analysis showed that the RR of mortality rate ranged from 0.77 to 1.00 with a relatively narrow confidence interval （P 〈 0.05）. However, the number needed to treat having a minor lower limit of the range （7-5096 patients） implied that certain SAP patients could still potentially prevent death by antibiotic prophylaxis. CONCLUSION： Current evidences do not support prophylactic antibiotics as a routine treatment for SAP, but the potentially benefited sub-population requires further investigations.