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中文摘要：
脓毒症的发病率不断攀升,病死率仍然居高不下。研究发现,脓毒症的病理生理机制十分复杂。随着疾病进展,机体免疫系统调节机制失衡,易于出现免疫抑制状态。这是造成患者二次机会感染以及死亡的重要原因。近年来,人们日益重视针对机体紊乱状态的免疫调理治疗,开展了以各类免疫细胞为调节靶点的基础和临床研究。多种重组细胞因子、抗体及制剂等表现出良好的生物学活性,部分药物现已经进入临床试验阶段,并且在改善脓毒症患者免疫状态等方面取得初步疗效。因此,免疫调理治疗具有重要研究前景和临床意义。
英文摘要：
The morbidity of sepsis gradually elevates every year with a high mortality.Decades of study reveal a complicated pathophysiological mechanism in the development of sepsis.The balance of regulation by immune system appears to be lost during sepsis,and is prone to immunosuppression,which result in secondary opportunistic infection and even death.Recently,immunomodulatory therapy aiming to regulate host immune response attracts more attentions.In latest 20 years,amounts of study and clinical trials targeted to regulation of various immune cells functions have been reported.Several recombinant cytokines,antibodies and chemical reagents perform well in biological activity.Some of them have already entered into clinical trials and shown satisfied effects to improve immune functions.Immunomodulatory therapies possess widely prospects in investigation and clinical significance.
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