中文摘要：

目的通过对中国东部沿海发热伴血小板减少综合征（SFTS）高发区舟山市患者的临床特点及致死危险因素进行分析，以期降低该病致死率。方法回顾性分析2011年6月至2016年6月温州医科大学附属舟山医院收治的107例SFTS患者的临床资料。根据其预后分为SFTS存活组和死亡组，采用病例对照的研究方法对两组的临床特征及实验室检查结果进行分析，评估预后相关危险因素。正态分布的计量资料比较采用独立样本t检验，偏态分布的采用Kolmogorov-Smirnov Z检验；两组分类资料比较采用卡方检验；对相关危险因素进行受试者工作特征（ROC）曲线分析和多因素非条件Logistics回归分析。结果107例患者中死亡17例，病死率为15.9%。SFTS死亡组患者2种及以上基础疾病、意识障碍、活化部分凝血活酶时间（APTT）、CK、乳酸脱氢酶（LDH）、序贯性器官功能衰竭评分（SOFA）均显著高于生存组（均P〈0.05）；死亡组患者Ca2＋、纤维蛋白原（FIB）水平均显著低于存活组（均P〈0.05）。将上述各组计量指标进行ROC曲线分析，计算出其截断值（cut-off值），将其作为最佳诊断阈值纳入多因素Logistics回归分析，结果显示Ca2＋〈1.625 mmol/L、APTT〉73.45 s、SOFA评分〉9是影响SFTS患者预后的独立危险因素（OR值分别为6.947、8.459和11.770，均P〈0.05）。结论血Ca2＋、APTT、SOFA评分是影响SFTS患者预后的独立危险因素，对预后评价具有一定的诊断价值。

英文摘要：

ObjectiveTo analyze the clinical features and risk factors for mortality of patients with severe fever with thrombocytopenia syndrome （SFTS） in Zhoushan, the eastern coastal of China with high incidence of severe fever with thrambocytopenia syndrome bunyavirus infection, to provide reference for reducing the mortality rate of SFTS.MethodsClinical data of 107 cases of SFTS from Zhoushan Hospital during June 2011 to June 2016 were retrospectively analyzed. According to the prognosis, patients were divided into survival group and death group. The clinical features and the laboratory results were analyzed with a case-control method to analyze the prognostic factors. Normal distribution data were compared with the independent t test. Kolmogorov-Smirnov Z test were used in data with skewness distribution. Categorical data were analyze by chi-square test. The related risk factors were analyzed with the receiver-operating characteristic （ROC） curve and multivariate unconditioned logistics regression analysis.ResultsSeventeen cases among 107 STFs patients died, yielding the mortality rate of 15.9%. The proportion of patients suffering from two or more underlying diseases, with disorders of consciousness, activated partial thromboplastin time （APTT）, the level of creatine kinase （CK）, lactate dehydrogenase （LDH） as well as sepsis-related or sequential organ failure assessment （SOFA） score in death group were all significantly higher than those in the survival group （all P〈0.05）. The Ca2＋ level and fibrinogen level in death group were significantly lower than those in the survival group （both P〈0.05）. Indexes mentioned above were analyzed by ROC curve, and the calculated cut-off value was set as the optimal diagnostic thresholds. These data were then included into the multivariate logistic regression analysis. It turned out that Ca2＋ 〈1.625 mmol/L, APTT 〉73.45 s, SOFA scores 〉9 were the independent risk factors for mortality of SFTS （OR=6.947, 8.459 and 11.770, respectively, a