中文摘要：

由于滥用抗生素,人类致病菌的耐药日益成为全球性的公共卫生难题。据统计,细菌感染80%以上与细菌生物被膜有关。近年来,有关细菌群体感应和细菌生物被膜的形成乃至机理已有报道,但就群体感应与细菌生物被膜的关系却报道较少,而揭示二者之间的关系可能会为解决致病菌耐药问题提供一个全新的思路。本文立足群体感应和细菌生物被膜的形成机制,结合本课题组的阶段性研究内容,拟阐明细菌群体感应与生物被膜形成的关系。

英文摘要：

Due to the overuse of anti-microbiological drugs,the resistance of pathogenic bacteria is of great attention for the international public health.According to previous reported literatures,over 80% bacterial infection was relative and contained to biofilm.Recently,many literatures have studied the pathogenic mechanism of quorum sensing（QS） and biofilm,but the relationship between QS and biofilm was hardly published.Revealing the relationship between the two can provide a new strategy for resolving the resistance of pathogenic bacteria.Based on mechanism of QS and biofilm formation and our research progress,the relationship between bacterial QS and biofilm formation is reviewed.