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Effect of Enteral Nutrition Formula on Fat Absorption and Serum Free Fatty Acid Profiles in Rat with Short-Bowel Syndrome

ISSN号：1001-604X
期刊名称：《中国化学：英文版》
时间：0
分类：R574[医药卫生—消化系统;医药卫生—临床医学;医药卫生—内科学]
作者机构：[1]The First Clinical Medical College, Nanjing Medical University, Nanjing, Jiangsu 210029, China, [2]Key Laboratory of Analytical Chemistry for Life Science (Ministry of Eduction of China), Department of Chemistry, Nanjing University, Nanjing, Jiangsu 210093, China
相关基金：Project supported by the National Science Fundation for Distinguished Young Scholars （No. 20325518） and Creative Research Groups （No. 20521503）, the Key （No. 20535010） and General Programs （No. 20275017） from the National Natural Science Foundation of China.

作者：周建农[1], 谭力[2], 王学浩[1], 鞠熀先[2]

关键词：血清脂肪酸, 脂肪吸收率, 气相色谱, 短肠综合病症, 肠道营养, serum fatty acid profile, fat absorptivity, gas chromatography, short bowel syndrome, enteral nutrition formula, rat

中文摘要：

与短肠的症候群(SBS ) 在老鼠在胖被吸收，免费的丰满的酸介绍的浆液和肠的形态学上包含长链 triglycerides (坦克登陆艇) 和中等的链 triglycerides (MCT ) 或 L 精氨酸(Arg ) 的 enteral 营养的效果用煤气的层析被学习。28 只 Sprague-Dawley 老鼠随机被分到作为控制用坦克登陆艇喂的 4 groups:sham 操作；分别地用坦克登陆艇， MCT/LCT，和 Arg/LCT 喂的 85% 小肠切除术。SBS 老鼠显示出胖吸收率的减少。与 MCT 补充的 Enteral 营养能增加胖吸收率。L 精氨酸提高了 enteral 营养与胖吸收率的举起被联系，可能由于它残余上的 enterotrophic 效果小肠 mucosa。坦克登陆艇组显示出全部的免费的丰满的酸和减少的必要的丰满的酸内容的重要缺乏，它在另外的二个 SBS 组被改进。

英文摘要：

The effects of enteral nutrition containing long chain triglycerides （LCT） and medium chain triglycerides （MCT） or L-arginine （Arg） on fat absorbability, serum free fatty acid profiles and intestinal morphology in rats with short-bowel syndrome （SBS） were studied using gas chromatography. Twenty-eight Sprague-Dawley rats were randomly assigned to 4 groups： sham operation fed with LCT as control; 85% small bowel resection fed with LCT, MCT/LCT, and Arg/LCT, respectively. SBS rats showed a decrease of fat absorptivity. Enteral nutrition supplemented with MCT could increase fat absorptivity. L-Arginine enhanced enteral nutrition was associated with the elevation of fat absorptivity, possibly due to its enterotrophic effect on remnant small bowel mucosa. LCT group showed a significant deficiency of total free fatty acid and the decreased essential fatty acid content, which was improved in other two SBS groups.