心房颤动是临床常见的持续性心律失常,发病率随着年龄增加而逐渐升高,致死和致残率高。目前对心房颤动的治疗仍然缺乏有效的措施,其根本原因是心房颤动发生的分子机制未完全明确。新近的研究发现,炎症分子标志物如C反应蛋白、白介素、肿瘤坏死因子、热休克蛋白等在心房颤动的心房结构重构中扮演了重要角色,而抗炎在心房颤动的临床治疗中发挥着重要作用。现就近年来炎症相关心房颤动的发生和临床治疗进展进行综述。
Atrial fibrillation is a common and persistent arrhythmia. The incidence increases with the increasing of age, and the mortality and disability are high. At present, there is still a lack of effective measures for the treatment of atrial fibrillation. The underlying reason is that the molecular mechanism of atrial fibrillation is not completely clear. Recent studies have found that inflammatory markers such as C- reactive' protein, interleukin, tumor necrosis factor, heat shock protein involved in atrial remodeling. The article reviews the recent progress in the oeeurrence and clinical treatment of inflammation related atrial fibrillation.