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中文摘要：
钙离子（Ca^2＋）是调节突触前神经递质的胞吐释放的关键离子信号．作为胞内最普遍存在的钙离子感受器的钙调蛋白（CaM）被发现能通过与多种蛋白的相互作用，调控着突触小泡的生发、运输及再填充，从而传递胞内Ca2＋浓度变化的信号，对神经递质的释放及突触电生理活动起到至关重要的调控作用．本文综述了CaM及其结合蛋白是如何参与对突触小泡的胞吐释放和胞吞恢复的调控，并探讨了其中可能的分子机制．
英文摘要：
Calcium （Ca2＋ ） is a key ion signal known as the regulator of the presynaptic exocytotic release of neurotransmitters. As a most ubiquitous intracellular calcium sensor, calmodulin （CAM）, together with multiple binding proteins, transmits the variation of intracellular calcium and regulate the steps of various processes of vesicle priming, trafficking and refilling , which determine for the secretion of neurotransmitters. It has been discussed how calmodulin and calmodulin-binding proteins regulate the exocytosis and endocytosis of presynaptic vesicles and the possible mechanisms involved in this review.
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