中文摘要：

通过原子转移自由基聚合（ATRP）合成了一种带有活性-NH2基团的温度敏感性亲水型共聚物P（NiPAAm—co—DMAA），并将其作为引发剂，合成了P（NiPAAm—co—DMAA）-co—P（L-Ala），其分子量分布（PDI）在1．3左右．聚合物通过自组装形成纳米胶束．透射电镜（TEM）结果表明，胶束大小200～300nm，具有明显的核壳结构．共聚物的最低临界溶解温度（LCST）为45．5℃．温度低于LCST时，聚合物溶解形成胶束；高于LCST时，胶束解离，聚合物不溶．聚合物对温度的响应是快速而可逆的．

英文摘要：

A novel temperature-sensitive amphiphilic copolymer of P（NiPAAm-co-DMAA） with active -NH2 group was synthesized by ATRP, which was used as initiator of amino acid polymerization. The PDI of P（NiPAAm-co-DMAA）-co-P（L-Ala） is about 1.3. This polymer could form temperature-sensitive micelle by self-assembly. The diameter and distribution of micelle were observed by TEM. The results show that the siza of micelle is about 200-300 nm and the micelle has obvious core-shell structure. LCST of copolymer is 45.5 ℃. When temperature is under LCST, the copolymer is soluble and form temperature-sensitive micelle. When temperature is above LCST, the micelle dissociate and copolymer is insoluble. Its response to temperature is quickly and reversible.