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中文摘要：
金属蛋白质组学旨在研究生物体系内金属蛋白质的分布、组成、结构、特征、功能、金属结合环境及其在疾病诊断和药物开发中的应用。各种先进核分析技术在金属蛋白质组学研究中有着广泛的用途。本文评述了分子活化分析、同步辐射X荧光分析、同位素示踪等在金属蛋白质种态分析方面的应用,以及穆斯堡尔谱学、同步辐射X射线吸收光谱和中子散射等在金属蛋白结构表征方面的应用,对各种方法的特点和局限作了简单说明。基于大科学装置的中子散射和同步辐射技术的联用,有望在金属蛋白质组学中作出重要贡献。
英文摘要：
Metalloproteomics is an emerging scientific field. Its research target is focused to investigate the distributions and compositions of all metalloproteins in a proteome, their structural and functional characterization, and their structural metal-binding moieties. Various nuclear analytical techniques, such as molecular activation analysis, X-ray fluorescence, isotope tracer, Moessbauer spectrometry, X-ray absorption spectrometry, and neutron scattering are powerful tools to study a number of the basic issues in metalloproteomics. In this paper, the applications of the mentioned nuclear techniques in this field are selectively outlined, along with their advantages and limitations.
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