32名Ⅱ型糖尿病(T2DM)患者随机分为运动组(E组,n=16)和对照组(C组,n=16),E组进行12周低强度(50% VO2max)有氧运动,C组保持日常生活习惯不变.分别于实验前后测定胰岛素抵抗指数(IRI)以及自主神经功能参数,包括心率变异性(HRV)和压力反射敏感性(BRS).结果显示,实验后,E组IRI较实验前显著性下降(P<0.05),C组则无显著性变化(P>0.05);口服葡萄糖耐量实验(OGTT)后,E组和C组HRV TP(总功率)、LFn(标准低频功率)和LF/HF(低频功率/高频功率)均较安静空腹时显著性升高(P<0.05或P<0.01),E组HRVLFn和LF/HF的变化率较实验前显著性升高(P<0.01),C组HRV TP、LFn和LF/HF的变化率与实验前比较无显著性差异(P>0.05).相关分析显示,△LFn与△IRI显著负相关(P<0.01).以上结果表明:12周低强度有氧运动改善了T2DM患者OGTT后的交感调制钝化反应,其机制可能与胰岛素抵抗减轻有关.
Thirty-two type Ⅱ diabetes mellitus (T2DM) patients were divided randomly into exercise group (EG,n =16) and control group (CG,n =16).People of EG performed a 12-week low intensity aerobic exercise(50% VO2max),while those of CG maintained their normal lifestyle.Insulin resistance index (IRI) and parameters of autonomic nervous function including heart rate variability (HRV) and baroreflex sensitivity (BRS) were determined before and after test.The results showed that,after test,IRI of EG reduced (P<0.05) but that of CG had no change (P>0.05) compared with pre-test;after oral glucose tolerance test (OGTT),HRV TP,LFn and LF/HF in both EG and CG increased compared with fasting state (P<0.05 or P<0.01);change rates of HRV LFn and LF/HF of EG were higher (P<0.01) while those of CG had no difference than pre-test (P>0.05).Correlation analysis displayed that there was negative correlation between △LFn and △IRI (P<0.01).Data above indicated that low intensity aerobic exercise of 12-week improved autonomic modulation after OGTT in T2DM,which may be related to amelioration of insulin resistance.