中文摘要：

目的探讨肾陛高血压大鼠动脉功能重构及K^＋通道开放剂的作用。方法40只SD大鼠，随机分为四组，A组为对照（假手术组），其余3组通过“两肾一夹”（2K1C）方法制成肾性高血压模型，分别为B：2K1C组，C：吡那地尔组，D：吡那地尔＋优降糖组。术后3周通过灌胃途径予以C、D相应药物干预。术后每周检测各组大鼠血压。术后6周处死，分别取四组大鼠左股动脉、腹主动脉，行离体动脉环试验，观察对氯化钾（KCl）、去甲肾上腺素（NE）、硝酸甘油（NTG）的反应变化。结果1周后大鼠血压开始升高（P〈0．05），3周达高峰（P〈0．01），心率无明显变化（P〉0．05）。经灌胃途径予以相应药物处理3周后观察结果。6周后C组血压较B组降低（P〈0．05），D组血压较C组升高（P〈0．05）。股动脉及腹主动脉收缩反应，B组对KCl、NE的收缩反应较A组增强（P〈0．05），对硝酸甘油的舒张反应减弱（P〈0．05）。C组对KCl、NE的收缩反应较B组减弱（P〈0．05），对硝酸甘油的舒张反应增强（P〈0．05）。结论Katp通道开放剂吡那地尔可减弱肾性高血压动脉功能改变，提示K^＋通道在RHR血管功能重构中可能发挥一定作用。

英文摘要：

Objective To study the role of K^＋ opener in arterial function remodeling of rats with renal hypertension（RH）. Methods Forty 6- weeks- old SD rats were randomly divided into group A（control group）, group B（2K1C group）, group C（pinacidil group）, and group D（pinacidil ＋ glibenclamide group）, 10 rats in each group. Three weeks after a renal hypertension model of rat was established with 2K1C, rats in groups C and D were given drugs by gastric lavage. Blood pressure of rats in different groups was then measured each week. The rats were killed after 6 weeks with their left femoral artery and abdominal aorta removed for in vitro arterial circle experiments. Effect of KCl, NE and NTG on blood pressure was observed. Results The blood pressure of rats in groups C and D began to increase one week after the model was established（P〈0.05）, and reached its peak three weeks after the model was established（P〈0.01）, with no significant change in heart rate. The blood pressure was lower in group C than in group D（P〈0.05） 6 weeks after drugs were given by gastric lavage. The effect of KCl and NE on systolic pressure was stronger while the effect of NTG on diastolic pressure was weaker in group B than in group A（P〈0.05）. The effect of KCl and NE on systolic pressure was weaker while the effect of NTG on diastolic pressure was stronger in group C than in group B（P〈0.05）. Conclusion K^＋ opener, pinacidil, can improve the arterial function in rats with renal hypertension, and may play a certain role in arterial function remolding of rats with renal hypertension.