中文摘要：

Amphiphilic diblock 共聚物， methoxy poly (乙烯乙二醇)-poly(lactic 酸)(MePEG-PLA ) ， poly 从 DL 减水乳酸和 methoxy 的单体被综合(乙烯乙二醇) 面对亚锡的 octoate 由一枚戒指打开体积聚合。他们的化学结构和物理性质用 FTIR， NMR， GPC，和荧光光谱学被调查。为了作为胶体的药搬运人，估计可行性， nimodipine (ND ) 被 phaseseparation/dialysis 方法装进 MePEG-PLA 块共聚物 nanoparticles。吝啬的直径和装载 ND 的 MePEG-PLA 共聚物 nanoparticles 的药装载效率取决于共聚物和药 / 聚合物的 PLA/MePEG 块作文在准备喂比率。NMR 学习证实 nimodipine 被骗诱进 MePEG-PLA 共聚物 nanoparticles 的恐水病的内部核心，吸水的木钉链位于装载药的聚合物 nanoparticles 的表面。在 vitro，版本实验从 MePEG-PLA 共聚物 nanoparticles 展出了 nimodipine 的持续版本行为，没有任何爆炸效果。

英文摘要：

Amphiphilic diblock copolymers, methoxy poly （ ethylene glycol）-poly（lactic acid） （MePEG-PLA）, were synthesized from monomers of DL-lactide and methoxy poly （ethylene glycol） by a ring opening bulk polymerizatiou in the presence of stannous octoate. Their chemical structure and physical properties were investigated using FTIR, NMR, GPC, and fluorescence spectroscopy. To estimate the feasibility as colloidal drug carrier, nimodipine （ND） was loaded into MePEG-PLA block copolymer nanoparticles by phaseseparation/dialysis method. The mean diameter and drug loading efficiency of ND-loaded MePEG-PLA copolymer nanoparticles depended ou PLA/MePEG block composition of the copolymer and drug/polymer feed ratio in preparatiou. NMR study confirmed that nimodipine was entrapped into the hydrophobic inner core of MePEG-PLA copolymer nanoparticles and hydrophilic PEG chains were located ou the surface of the drug-loaded polymer nanoparticles. In vitro release experiments exhibited the sustained release behavior of nimodipine from MePEG-PLA copolymer nanoparticles, without any burst effect.