中文摘要：

肠纤维化是炎症性肠病（inflammatory bowel disease,IBD）的并发症,其主要病理表现为以胶原为主的细胞外间质（extracellular matrix,ECM）在肠组织的过度合成和异常沉积。其中,溃疡性结肠炎（ulcerative colitis,UC）以直肠和结肠的浅表性炎症病变为主,其肠纤维化一般只限于粘膜下层;而克罗恩病（Crohn disease,CD）则是以全肠道均可受累的透壁性炎症为特征，导致肠壁各解剖层均发生ECM异常沉积，最终形成肠道狭窄、发生肠梗阻，严重影响着患者生活质量。

英文摘要：

Intestinal fibrosis is the complications of inflammatory bowel disease（ IBD）,intestinal myofibroblast cells are the key to intestinal fibrosis. Intestinal myofibroblasts and its interaction with inflammatory cells play an important role in IBD-related intestinal fibrosis.