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姜黄素对重离子辐射损伤小鼠睾丸组织的防护作用研究

ISSN号：1007-4627
期刊名称：原子核物理评论
时间：2014
页码：101-105
分类：Q691[生物学—生物物理学] R852.7[医药卫生—航空、航天与航海医学;医药卫生—临床医学]
作者机构：[1]中国科学院近代物理研究所,兰州730000, [2]中国科学院重离子束辐射生物医学重点实验室,兰州730000, [3]甘肃省重离子束辐射医学应用基础重点实验室,兰州730000, [4]中国科学院大学,北京100049
相关基金：国家重点基础研究发展计划（973计划）项目（2010CB834202）;国家自然科学基金项目（10835011）;甘肃省重大科技专项项目（0702NKDA045,0806RJYA020）;中国科学院西部之光人才培养计划项目（XB106012）
相关项目：辐射诱导的p73变异体对肿瘤细胞凋亡的调控作用

关键词：姜黄素, 小鼠, 12C6+离子, 辐射防护, Curcumin, mouse, 12C6＋ ion, radioprotection

中文摘要：

探讨姜黄素（Curcumin，简称Cur）对重离子辐射损伤小鼠睾丸组织的防护作用。小鼠灌胃不同剂量的Cur后给予4Gy剂量挖C0＋离子束全身单次照射。24h后对小鼠睾丸组织形态学变化进行观察，并测定丙二醛（MDA）含量、超氧化物歧化酶（SOD）活性和过氧化氢酶（CAT）活性。结果显示：中、高浓度Cur预处理组对小鼠睾丸组织的形态具有较好的保护作用；低、中浓度Cur预处理组MDA含量显著降低（P〈0．05）；与单纯照射组相比，低浓度Cur预处理组SOD活性水平和中浓度Cur预处理组CAT活性水平显著提高（P〈0．05）。结果表明：Cur对重离子全身辐射小鼠的抗氧化系统有一定的激活效应，对辐射损伤有一定的防护作用，其机制可能与Cur清除自由基，保护脂质和蛋白质有关。

英文摘要：

The protective effect of Curcumin （Cur） against the irradiation damage of testis in mice induced by 12C6＋ ion beams was studied. Male Kung-Ming mice were exposed to whole body uniformly irradiated with 12C6＋ ion beams at 4 Gy after pretreated with Cur of different concentration. Then histological alterations were observed. Moreover, malonaldehyde （MDA） level, superoxide dismutase （SOD） activity and catalase （CAT） activity were also measured at 24 h after irradiation. The result showed that middle and high dose Cur pretreated have a good protective effect. Compared with irradiated group, MDA level decreased dramatically in the group of pretreatment with low and middle dose Cur （P 〈 0.05）. On the contrary, SOD activity in the pretreated group with low dose Cur significantly increased （P 〈 0.05）. Similarly, CAT activity in the pretreated group with middle dose Cur significantly increased （P 〈 0.05）. Data suggested that Cur could activate antioxidant system of testis in mice induced by12C6＋ ion beams, it have some protective effect to radiation damage. The mechanism may involve in its scavenging reactive oxidant species and then protecting lipid and protein capability.

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