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中文摘要：
本文将三维荧光光谱与二阶校正方法相结合用于人体血浆样中的中药药理活性成分川芎嗪和阿魏酸含量的直接测定。尽管预测样存在血浆内源荧光物质的基体干扰,但由于该方法基于＂数学分离＂的思路和具有＂二阶优势＂,仍能对荧光光谱严重重叠的血浆样中的目标分析物进行直接同时定量测定,为川芎嗪和阿魏酸在体内的代谢监控及其药效研究提供了一种新思路。获得的预测样中川芎嗪和阿魏酸的平均回收率分别为（95.7±2.2）%和（100.8±2.5）%。该方法简单、快速,结果可靠。
英文摘要：
A simple and rapid method using excitation-emission matrix fluorescent spectra coupled with second-order calibration method based on alternating trilinear decomposition（ATLD） algorithm was proposed for simultaneous quantitative determination of ligustrazine and ferulic acid in human plasma samples.This methodology avoids of tedious extraction and separation steps and overcomes the problem caused by serious fluorescence signal overlapping between analytes and plasma matrices.When the right component number was chosen,reliable result was obtained： the average recoveries of ligustrazine and ferulic acid in prediction samples were（95.7±2.2）%and（100.8±2.5）%,respectively,which means that a new underlying method for monitoring the metabolism of ligustrazine and ferulic acid in human plasma.
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