中文摘要：

流行病学和基础研究表明阿尔茨海默病（Alzheimert＇s disease，AD）与2型糖尿病（type 2 diabetes mellitus，T2DM）存在密切关联：T2DM是AD的危险因素之一；而AD脑内也出现胰岛素信号异常、胰岛素抵抗状态，因而被称为“第3类型的糖尿病”。近年来治疗T2DM的新药——胰高血糖素样肽-1（glucagon-1ike peptide-1，GLP-1）及其类似物，已被证实具有神经保护作用，且能改善AD模型的记忆和认知功能，为AD治疗药物的研究提供了新的策略。

英文摘要：

Epidemiological evidence and basic research have shown that there is a close relationship between Alzheimer＇s disease （AD） and type 2 diabetes mellitus （T2DM）. T2DM is one of the risk factors for AD, while AD brain appears insulin signaling abnormity and insulin resistance, supporting the hypothesis that AD is ＂type 3 diabetes＂. Recent new drugs anti-T2DM--glucagon-like peptide-1 （GLP-1） and its analogs, have shown neuroprotective effects and can improve memory and cognitive function of AD model, which holds promise as a novel strategy for AD treatmant