中文摘要：

目的研究幽门螺杆菌和真菌感染在胃病患者中的病理诊断效果及意义,提高胃溃疡、胃癌等胃病临床诊断,为其治疗方法提供参考。方法选取2015年1-9月医院诊治的300例胃病患者临床资料,按疾病类型不同分为胃癌组120例和胃溃疡组180例,在胃镜下获取胃组织黏膜标本,行常规石蜡切片及HE及Giemsa染色,分析两组患者中幽门螺杆菌和真菌感染检出率,对采集的数据采用SPSS18.0软件进行统计分析。结果 120例胃癌患者中幽门螺杆菌及幽门螺杆菌混合真菌检出率分别为68.3%及50.8%,显著高于胃溃疡患者的60.6%及34.4%（P〈0.05）;胃癌患者真菌检出率为35.0%,显著低于胃溃疡患者的56.1%,差异均有统计学意义（P〈0.05）;300例胃病患者中HE染色下幽门螺杆菌为蓝色,单个细菌表现为短杆状;而真菌在HE染色下表现为大波浪形状;胃病患者Giemsa染色幽门螺杆菌表现为紫色,真菌在Giemsa染色下分布比较情清晰。结论胃病患者在临床诊断时幽门螺杆菌、真菌及两种病原菌同时感染率较高,应根据检测结果合理治疗。

英文摘要：

OBJECTIVE To explore the clinical effect and significance of pathological diagnosis of Helicobacter pylori and fungal infections in patients with gastric diseases so as to improve the clinical diagnosis of gastric diseases such as gastric ulcer and gastric cancer and provide guidance for the treatment.METHODS A total of 300 patients with gastric diseases who were treated in the hospital from Jan 2015 to Sep 2015 were enrolled in the study and divided into the gastric cancer group with 120 cases and the gastric ulcer group with 180 cases according to the type of disease.The gastric mucosal tissue specimens were collected by using gastroscope and treated with routine paraffin sections and HE and Giemsa staining.The isolation rates of H.pylori and fungi were observed and compared between the two groups of patients,and the statistical analysis of data was performed with the use of SPSS18.0software.RESULTS The isolation rates of H.pylori and H.pylori mixed with fungi were respectively 68.3% and50.8%in the 120 gastric cancer patients,significantly higher than 60.6% and 34.4%in the gastric ulcer patients（P0.05）.The isolation rate of fungi of the gastric cancer patients was 35.0%,significantly lower than 56.1%of the gastric ulcer patients（P0.05）.Among the 300 patients with gastric diseases,the H.pylori strains were blue under the HE staining,each single strain showed short rod;while the fungi were characterized by big wave shape under the HE staining.The H.pylori strains showed purple under the Giemsa staining,and the fungi showed clear distribution under the Giemsa staining.CONCLUSIONThe incidence rates of H.pylori and fungal infections are simultaneously high in the patients with clinical diagnosis of gastric diseases,and it is necessary to conduct the appropriate treatment on the basis of detection results.