Time-dependent structure analysis theory has been proved to be more accurate and reliable compared to commonly used methods during construction. However, so far applications are limited to partial period and part of the structure because of immeasurable artificial intervention. Based on the building informa-tion model (BIM) and four-dimensional (4D) technology, this paper proposes an improves structure analysis method, which can generate structural geometry, resistance model, and loading conditions automatically by a close interlink of the schedule information, architectural model, and material properties. The method was applied to a safety analysis during a continuous and dynamic simulation of the entire construction process. The results show that the organic combination of the BIM, 4D technology, construction simulation, and safety analysis of time-dependent structures is feasible and practical. This research also lays a foundation for further researches on building lifecycle management by combining architectural design, structure analysis, and construction management.