中文摘要：

目的研究高压环境对人耳蜗的影响,弥补试验手段不足导致的耳蜗在高压环境下听力行为特征研究的缺失,为今后对耳蜗进行针对性研究提供新的思路。方法基于健康人耳蜗CT扫描图像,结合自编程序,利用PATRAN软件建立三维螺旋耳蜗有限元模型。应用NASTRAN软件进行流固耦合频率响应分析和瞬态响应分析,通过数值模拟方法研究高压对耳蜗的影响。结果基底膜12 mm处与镫骨底板中心（卵圆窗的中心）处位移比值模拟结果与已报道的试验结果相吻合,验证了所建模型的正确性。高压环境下,耳蜗中基底膜特征频率点的幅值随着压强的增大而不断减小。结论高压环境最终导致人耳听力的降低。研究结果为临床上研制防治高压的缓冲装置提供理论支撑。

英文摘要：

Objective To study the effects of high pressure environment on human cochlea,so as to supplement inadequate study on cochlea behavior under high pressure conditions due to insufficient experimental methods,and provide new ideas for the targeted research on cochlea in future. Methods Based on CT scan images of normal human cochlea and combined with self-compiling program and the software PATRAN,a three-dimensional finite element model of spiral cochlea was constructed. The fluid-solid coupling frequency response analysis and transient response analysis were made by using NASTRAN. The effect of high pressure on cochlea was then investigated by numerical simulation. Results The simulated results of ratio of displacement at 12 mm from basilar membrane to that at the oval window were consistent with those reported in the literature,which verified the correctness of the model. In high pressure environment,the amplitude of cochlea basilar membrane at characteristic frequency point would decrease with the pressure increasing. Conclusions High pressure conditions can ultimately lead to the loss of human hearing. The research findings provide the theoretical support for developing high pressure buffer devices in clinic.