Respirasome,执行细胞的呼吸的一台巨大的分子的机器,自从它的发现,获得了成长注意,因为呼吸是在几乎所有生活动物的最不可缺少的生物过程。respirasome 的概念更新了我们呼吸的链组织的理解,并且最最近, respirasome 的结构从清华大学由 Yangs 组解决了(Gu 等。自然 237 (7622 ): 639-643, 2016 ) 第一在这台巨大的分子的机器以内介绍了详细相互作用,并且为药设计提供了重要信息并且屏蔽。然而,细胞的呼吸的学习通过了长历史。这里,我们简短显示出呼吸的链调查的 detoured 历史,然后描述了 respirasome 的令人惊讶的结构。
Respirasome, a huge molecular machine that carries out cellular respiration, has gained growing attention since its discovery, because respiration is the most indis- pensable biological process in almost all living crea- tures. The concept of respirasome has renewed our understanding of the respiratory chain organization, and most recently, the structure of respirasome solved by Yang's group from Tsinghua University (Gu et al. Nature 237(7622):639-643, 2016) firstly presented the detailed interactions within this huge molecular machine, and provided important information for drug design and screening. However, the study of cellular respiration went through a long history. Here, we briefly showed the detoured history of respiratory chain investigation, and then described the amazing structure of respirasome.