中文摘要：

尽管金 nanoshells 广泛地被看作为 biomedicine 使用的有希望的 photothermal nanomaterials 之一，高度花费的、低产量和差的稳定性严重地在临床的试用限制他们的潜在的申请。此处，硅石 nanorattles (GSN ) 上的柔韧的金 nanoshells 被作为一个稳定并且盖住的代理人采用 polyvinylpyrrolidone (PVP ) 的一个改进调停种子的方法容易在高收益准备。现在的方法很简单、有效、可再现并且能很好控制金 nanoshells 的生长过程。同样准备的 GSN 有狭窄的尺寸分布(< 10 ? 在标准差的 %) 。而且，在为金 nanoshells 的生长使用的答案的 Au 的利用率增加 70 ?% 比那在以前的方法。结果的 GSN 在放超过 6 以后有好结构的稳定性 ? 月由于 PVP 的保护。更重要地，在 vivo 并且在 vitro，有毒的研究显示 GSN 有好 biocompatibility。我们相信我们的准备方法将显著地为 biomedicine 支持金 nanoshells 的使用。

英文摘要：

Although gold nanoshells are widely considered as one of the promising photothermal nanomaterials used for biomedicine, the high cost, low yield and poor stability severely limit their potential application in clinical trials. Herein, robust gold nanoshells on silica nanorattles （GSNs） were easily prepared in a high yield by an improved seedmediated method employing polyvinylpyrrolidone （PVP） as a stabilizing and capping agent. The present method is verysimple, effective and reproducible and can well control the growth process of gold nanoshells. The as-prepared GSNs have a narrow size distribution （〈10 % in standard deviation）. Furthermore, the utilization rate of Au in the solution used for the growth of gold nanoshells increases by 70 % than that in previous method. The resultant GSNs have a good structural stability after placing over 6 months due to the protection of PVP. More importantly, in vivo and in vitro toxic studies indicate that the GSNs have good biocompatibility. We believe that our preparation method will remarkably promote the use of gold nanoshells for biomedicine.