中文摘要：

转录因子CCAAT增强子结合蛋白β（CCAAT enhancer—binding proteinβ，C／EBPβ）是一类与DNA增强子区域结合的反式作用因子。近年来研究表明C／EBPβ在子宫中的表达参与了妊娠早期的胚胎发育和蜕膜化过程。C／EBPβ敲除小鼠表现为不孕和对蜕膜化刺激无反应，说明C／EBPβ是调节蜕膜化反应的一个重要调节因子。C／EBPβ调节蜕膜化过程中子宫内膜基质细胞的增殖和分化，促进蜕膜化标志分子催乳素（prolactin，PRL）和胰岛素样生长因子结合蛋白1（insulin-like growth factor binding protein 1，IGFBP-1）的表达。此外，C／EBPβ还可与蜕膜化相关的甾体激素、cAMP、FOX01等分子相互作用进而调节蜕膜化。本文综述了C／EBPβ在调控蜕膜化过程的研究进展。

英文摘要：

The transcription factor CCAAT enhancer binding protein beta （C/EBPβ） is a transcription factor that combines with the DNA promoter region. Recent years, studies identified the expression of C/EBPβ in uterus as a novel mediator of embryonic development and decidualization. Female mice lacking C/EBPβ gene are infertile and their uteri displayed a complete lack of response to a deciduogenic stimulus, indicating a critical role of this transcription factor in regulating the decidualization program. C/EBPβ involves in endometrial stromal cell proliferation and differentiation during decidualization, and promotes the expression of insulin-like growth factor binding protein 1 （IGFBP-1） and prolactin （PRL）. Besides, C/EBPβ regulates deeidualization via interacting with many other molecules participating in decidualization, such as hormones, cAMP and forkhead transcription factors of the Oclass 1 （FOXO1）. In this paper, the regulation of C/EBPβ in the uterine decidualization was reviewed.