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Etiology and prevalence of abnormal serum alanine aminotransferase levels in a general population in Northeast China
  • ISSN号:0366-6999
  • 期刊名称:《中华医学杂志:英文版》
  • 时间:0
  • 分类:Q51[生物学—生物化学] G521[文化科学—教育学;文化科学—教育技术学]
  • 作者机构:[1]Department of Hepatology, First Hospital, Jilin University, Changchun, Jilin 130021, China
  • 相关基金:This work was supported by the grants from the National S&T Surface Project of China (No. 30972611) and the National S&T Major Project of China (No. 2008ZX 10002-004).
中文摘要:

背景长期的肝疾病是在 China.Alanine aminotransferase (中高音)的主要负担能被用作 hepatocyte damage.In 的指示物这研究,我们在吉林在一张成年人口决定了提高的中高音的流行和病原学, 4072 个个人的一个总数在 18 和 79 年之间变老的 China.Methods 首先被会见,然后经历提高的中高音的流行是的 ultrasonography 和血 tests.Results 17.53% .The 大多数为中高音举起的显著风险因素非酒精

英文摘要:

Background Chronic liver diseases are a major burden in China. Alanine aminotransferase (ALT) can be used as an indicator of hepatocyte damage. In this study, we determined the prevalence and etiologies of elevated ALT in an adult population in Jilin, China. Methods A total of 4072 individuals aged between 18 and 79 years were first interviewed, and then underwent ultrasonography and blood tests. Results The prevalence of elevated ALT was 17.53%. The most noticeable risk factor for ALT elevation was non-alcoholic fatty liver disease (NAFLD) (accounting for 10.79%), metabolic syndrome (16.25%), or both (20.31%). The development of NAFLD occured mostly in female peasants and small businessmen with increased income, age, fasting plasma glucose, body mass index, triglyceridemia, and low-density lipoprotein and decreased education level, high-density lipoprotein. Elevated ALT frequently occured in low education level, male peasants and small businessmen with increased income, body mass index and' triglyceride who had NAFLD and/or metabolic syndrome. However, elevated ALT with infection of hepatitis B or C virus was not associated with metabolic disorders, but rather with gender, occupation and increased age. Conclusion The results from the current study demonstrate that elevated ALT is fairly high in the Northeast population (17.53%) and that the cause of its elevation is mostly due to NAFLD and metabolic syndrome.

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期刊信息
  • 《中华医学杂志:英文版》
  • 中国科技核心期刊
  • 主管单位:中国科协
  • 主办单位:中华医学会
  • 主编:
  • 地址:北京东四西大街四十二号
  • 邮编:100710
  • 邮箱:cmj@cma.org.cn
  • 电话:010-85158321
  • 国际标准刊号:ISSN:0366-6999
  • 国内统一刊号:ISSN:11-2154/R
  • 邮发代号:2-920
  • 获奖情况:
  • 1997、1998、1999年获中国科协优秀科技期刊择优资...,1992、1997年连续两年荣获全国优秀科技期刊和中国...,中国期刊方阵双高期刊
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  • 美国化学文摘(网络版),英国农业与生物科学研究中心文摘,荷兰文摘与引文数据库,荷兰医学文摘,美国生物医学检索系统,美国科学引文索引(扩展库),美国生物科学数据库,日本日本科学技术振兴机构数据库,中国中国科技核心期刊
  • 被引量:3319