一氧化氮(NO)作为信号分子在植物的生长发育中发挥着重要的调控功能。对其在信号转导中的作用机制的研究也不断深入,NO主要由依赖于cGMP的途径发挥作用。近年来,不依赖于cGMP途径的研究受到越来越多的关注。在不依赖于cGMP途径中,NO能直接对蛋白质进行修饰,行使其调控功能。本文综述了NO直接与蛋白质中的过渡金属形成金属亚硝酰化(metal nitrosylation)、对蛋白质半胱氨酸残基的S-亚硝酰化(S-nitrosylation)和酪氨酸残基的硝基化(tyrosine nitration)等蛋白质翻译后修饰,及其在NO介导的细胞信号转导途径中的作用。
Nitric oxide (NO) as a key signaling molecule plays crucial roles in plant growth and development. A decade-long investigation focused on the signal transduction pathway of NO. In plants, the signaling of NO mostly be realized via a cGMP-dependent pathway, until recently researchers are beginning to unravel the mechanisms underlying the cGMP-independent pathway. In this pathway, NO exerts its cellular effects through interacts with target proteins directly. This review discusses the post-translational modification of proteins triggered by NO, which includes metal nitrosylation, S-nitrosylation and tyrosine nitration in plants.