Rational design of a biosensor circuit with semi-log dose-response function in Escherichia coli
- ISSN号：1000-0712
- 期刊名称：《大学物理》
- 时间：0
- 分类：TP334.83[自动化与计算机技术—计算机系统结构;自动化与计算机技术—计算机科学与技术] Q55[生物学—生物化学]
- 作者机构：[1]Peking University Team for the International Genetic Engineering Machine Competition (iGEM), Peking University, Beijng 100871, China, [2]Peking-Tsinghua Joint Center for Life Sciences, School of Life Sciences, Peking University, Beijing 100871, China, [3]Center for Quantitative Biology, Peking University, Beijng 100871, China, [4]State Key Laboratory for Artificial Microstructures and Mesoscopic Physics, School of Physics, Peking University, Beijing 100871. China
- 相关基金：This work is part of the project for the 2010 team of Peking University in the international genetically engineered machine （iGEM） competition. H. Zhang. designed the project, performed the experiments and modeling simulation, and wrote the manuscript. Y. Sheng., A. Liu, and Q. Wu performed the experiments. Y. Lu and Z. Yin performed the modeling simulation. Y. Cao and W. Zeng performed the modeling simulation and wrote the manu- script. Q. Ouyang designed the project and wrote the manuscript. We would like to thank F. Hao, X. He, W. Wei, C. Xu, and L. Ji for their technical assistance; the BioBrick Foundation for providing DNA materials; and Anne O. Summers for supplying the plasmid carrying MerR gene. We thank Peking University for its financial support. This work is also partially supported by the National Nature Science Foundation of China （Nos. 10721463, 110740 09）, the National Basic Research Program of China （Nos. 2009CB918500, 2012AA02A702）, and the National Science Fund for Talent Training in Basic Science of China （Nos. J1030310, J1103205）.
作者：
Haoqian Zhang[1,2,3], Ying Sheng[1], Qianzhu Wu[1], Ao Liu[1], Yuheng Lu[1], Zhenzhen Yin[1], Yuansheng Cao[3,4], Weiqian Zeng[3,4], Qi Ouyang[3,4]
关键词：
大肠杆菌细胞, 合成生物学, 传感器电路, 剂量反应, 设计原理, 对数, 感应传感器, 逆向工程, synthetic biology, gene circuit design, reverse engineering, logarithmically linear sensing
中文摘要：
Correspondence： qi@pku.edu.cn
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